Endocrine Abstracts

We examined gastroenterocolonic tract condition at 92 patients with active acromegaly (male 30, female 66, age 26–78 y.o., most of the patients 45–59 y.o.). Gastroduodenoscopy (n=92) and colonoscopy (n=74) were performed. Median GH levels were 22.7 (12.5; 51) mMe/l, median IGF1 levels – 640 (507; 800) ng/ml.Esophagitis was diagnosed at 22 (23.9%) patients, incompetence of cardia – 33 (35.8%) patients. There was one case ...

Clinical case: A 51 year-old caucasian woman was admitted in the emergency room of our hospital with psicomotor agitation and confusion after four days of a profuse watery diarrhea, with 5 stools per day, abdominal cramps and vomiting. She started 500 mg of aspirin on her own initiative. Her medical profile included a type 2 diabetes treated with metformin 850 mg/12 hours and glyburide 7.5 mg/day, and hypertension treated with enalapril 20 mg/day. No renal imparement was docum...

Background: Adrenal venous sampling (AVS) is considered the gold standard for differentiating an aldosterone- producing adenoma (aPA) from bilateral adrenal hyperplasia (BAH).Objective: The aim of this study is to present our experience with this method in our hospital.Methods: We performed a retrospective analysis of 105 patients who underwent the AVS protocol at our centre between 2015 and 2022 for PA.Resul...

Background: The Covid 19 pandemic has significantly changed people’s lives. For patients with chronic diseases, social isolation and distancing have become a provocative factor in metabolic control disorders of varying degrees. Patients avoided hospital visits as much as possible due to fear of infection. Also for the representatives of the medical field, the pandemic has become the basis for new ways of consulting patients (remote, teleconsultation). The aim of the study...

Introduction: Progressive hirsutism and moderate to severe male-pattern balding in women requires exclusion of an adrenal or ovarian tumor.Case presentation: A 51-year-old lady presented with excessive hair on her face and lower abdomen of 1 year duration which affected her quality of life. Her menopause started 3 years ago. Her body mass index was 28.6 kg/m2. She had hair on her upper lip, chin, and lower abdomen; she had a Ferriman–Gall...

Introduction: Iodine deficiency disorders are considered as the most wide spread non infectious diseases of the humanity. Uzbekistan is in the zone of the severe iodine deficiency (ID). According to epidemiologic studies performed in 1998 endemic goiter (EG) prevalence was 80% whereas urinary iodine was <10 μg/l. In May, 2007 Uzbek government legislated the Salt Iodization Law and in 2009 ID evaluation was performed in the Uzbekistan using sentinel approach.<p cla...

2.788 inhabitant (726 men 1192 women and 870 children) were examined in mountain region of Adjara on thyroid gland pathology at the age from 1 to 75 (2003-2005 years). The investigated population was selected by ‘randomized method’. The data of ultrasonography, clinical and laboratory tests (defining T3, T4, TSH hormones, antibodies and iodine excretion in urine) were diagnostic criteria’s of thyroid gland pathology. To study risk factors of thyroid gland pathol...

We have revisited the actions of hormones from the anterior pituitary, notably TSH, on bone and bone cells. Traditionally, the bone loss in hyperthyroidism has been attributed solely to elevated circulating levels of thyroid hormones. The role of TSH, which is reduced in all forms of hyperthyroidism, as well as during thyroxine suppressive therapy for thyroid cancer, has never been investigated. We found that haploinsufficiency of the TSH receptor in mice led to bone loss with...

TESTOSTERONE-REPLACEMENT STIMULATED HYPERPROLACTINAEMIAR Sodi, R Fikri, M Diver, L Ranganath & J Vora*.Departments of Clinical Chemistry and Endocrinology*Royal Liverpool and Broadgreen University Hospital,Liverpool, UK. L7 8XP.Around half of all men with macroprolactinomas have hypogonadism and may require exogenous testosterone replacement. However, testoste...

Background: Use of metformin in women with polycystic ovary syndrome (PCOS) is becoming increasingly accepted and widespread but clinical practice is ahead of the evidence.Methods: We extracted results from the seven published studies of metformin use in PCOS that include control elements quantifiably similar to the experimental arm. We also restricted our analysis to the studies with a systematic longitudinal examination of ovulatory function and metabolic parameters....